Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Therapy Name | MEDI0639 |
Synonyms | |
Therapy Description |
MEDI0639 is a monoclonal antibody which binds DLL4 and prevents its interaction with Notch receptors, thereby inhibiting pathway activation, angiogenesis, and tumor growth (PMID: 22679110). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
MEDI0639 | MEDI-0639 | DLL4 Antibody 7 | MEDI0639 is a monoclonal antibody which binds DLL4 and prevents its interaction with Notch receptors, thereby inhibiting pathway activation, angiogenesis, and tumor growth (PMID: 22679110). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01577745 | Phase I | MEDI0639 | A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI0639 in Advanced Solid Tumors | Completed | USA | 0 |