Therapy Detail

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Therapy Name DZNeP
Synonyms
Therapy Description

DZNeP (3-Deazaneplanocin A) inhibits S-adenosylhomocysteine hydrolase, resulting in depletion of EZH2 and inhibition of H3K27 methylation, which may promote apoptosis in cancer cells (PMID: 3790170, PMID: 19638619).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DZNeP 3-Deazaneplanocin A EZH2 inhibitor 18 DZNeP (3-Deazaneplanocin A) inhibits S-adenosylhomocysteine hydrolase, resulting in depletion of EZH2 and inhibition of H3K27 methylation, which may promote apoptosis in cancer cells (PMID: 3790170, PMID: 19638619, PMID: 32508971).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
EZH2 Y641S diffuse large B-cell lymphoma decreased response DZNeP Preclinical - Cell culture Actionable In a preclinical study, treatment with DZNeP resulted in a slight increase in number of dead or sub-G1 cells and accumulation of DNA damage in a diffuse large B-cell lymphoma cell line harboring EZH2 Y641S in culture (PMID: 25605023). 25605023
SMARCB1 negative atypical teratoid rhabdoid tumor sensitive DZNeP Preclinical Actionable In a preclinical study, DZNep induced apoptosis and cell-cycle arrest and inhibited growth of SMARCB1-negative atypical teratoid rhabdoid tumor cell lines in culture (PMID: 23190500). 23190500
EZH2 Y641N diffuse large B-cell lymphoma predicted - sensitive DZNeP Preclinical - Cell culture Actionable In a preclinical study, DZNeP treatment resulted in an increase in the number of dead or sub-G1 cells and increased DNA damage in a diffuse large B-cell lymphoma cell line harboring EZH2 Y641N in culture (PMID: 25605023). 25605023

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status


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