Therapy Detail
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| Therapy Name | INCB054329 |
| Synonyms | |
| Therapy Description |
INCB054329 is BET inhibitor, which inhibits cell proliferation (Proceedings of the 106th Annual Meeting of the AACR; 2015; Abstract nr 3525). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| INCB054329 | INCB-054329 | BET Inhibitor (Pan) 27 | INCB054329 is BET inhibitor, which results in decreased expression of BET protein-regulated genes including MYC, potentially leading to decreased tumor cell proliferation (PMID: 30206163) |
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- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | colorectal cancer | not applicable | INCB054329 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, INCB054329 promoted apoptosis and decreased MYC expression in colorectal cancer cell lines in culture and demonstrated anti-tumor activity in colorectal cancer cell line xenograft models (AACR; 2015. Abstract nr 3525). | detail... |
| Unknown unknown | multiple myeloma | not applicable | INCB054329 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, INCB054329 treatment reduced MYC expression and proliferation of myeloma cell lines in culture, and inhibited tumor growth in myeloma cell line xenograft models (PMID: 30206163). | 30206163 |
Filtering
- Case insensitive filtering will display rows where any text in any cell matches the filter term
- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
Sorting
- Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|---|---|---|---|
| NCT02431260 | Phase I | INCB054329 | An Open-Label, Dose-Escalation Study of INCB054329 in Patients With Advanced Malignancies | Terminated |
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