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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD3514||AZD-3514||Hormone - Anti-androgens 27||AZD3514 binds to androgen receptor (AR) and inhibits its nuclear translocation and activation, and also inhibits AR protein expression, resulting in decreased tumor cell proliferation (PMID: 23861347, PMID: 30232143).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||prostate cancer||not applicable||AZD3514||Phase I||Actionable||In two Phase I trials, AZD3514 treatment resulted in more than 50% decrease of PSA level in 13% (9/70) of patients with castration-resistant prostate cancer, and an objective soft tissue response in 17% (4/24) of patients in one of the trials (PMID: 25920479).||25920479|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|