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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NSC348884||NSC-348884|NSC 348884||NSC348884 is a small molecule inhibitor of nucleophosmin 1 (NPM1), which has the potential to attenuate oligomerization and induce apoptosis in cancer cells (PMID: 18345031, PMID: 31462227).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NPM1 mutant||acute myeloid leukemia||sensitive||NSC348884||Preclinical||Actionable||In a preclinical study, acute myeloid leukemia cells harboring a NPM1 mutation were sensitive to NSC348884 as demonstrated by induced apoptosis (PMID: 21719597).||21719597|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|