Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : ckbsupport@jax.org
Therapy Name | OBP-801 |
Synonyms | |
Therapy Description |
OBP-801 is a histone deacetylase inhibitor belonging to the cyclic peptide class, which may induce both cell cycle arrest and apoptosis (PMID: 18292931, PMID: 23900601). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
OBP-801 | YM753|YM-753 | HDAC Inhibitor 38 | OBP-801 (YM753) is a histone deacetylase inhibitor belonging to the cyclic peptide class, which may induce both cell cycle arrest and apoptosis (PMID: 18292931, PMID: 23900601, PMID: 32277670). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
Unknown unknown | urinary bladder cancer | not applicable | OBP-801 | Preclinical - Cell culture | Actionable | In a preclinical study, OBP-801 treatment resulted in decreased cell viability in multiple human bladder cancer cell lines in culture (PMID: 27406983). | 27406983 |
Unknown unknown | Advanced Solid Tumor | not applicable | OBP-801 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, OBP-201 (YM753) inhibited growth of several solid tumor cell lines in culture and demonstrated anti-tumor activity in a colon cancer cell line xenograft model (PMID: 18292931). | 18292931 |
Unknown unknown | rhabdoid cancer | not applicable | OBP-801 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, OBP-801 treatment inhibited proliferation and induced apoptosis in rhabdoid tumor cell lines in culture, and inhibited tumor growth in cell line xenograft models (PMID: 32847975). | 32847975 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT02414516 | Phase I | OBP-801 | A Dose-Escalation Study of OBP-801 in Patients With Advanced Solid Tumors | Unknown status | USA | 0 |