Therapy Detail

Therapy Name PD-0325901 + Gedatolisib
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Gedatolisib PKI-587|PF-05212384 mTOR Inhibitor 48 PI3K Inhibitor (Pan) 34 Gedatolisib (PF-05212384) is an ATP-competitive inhibitor that targets phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, and may result in antitumor activity, including inhibition of tumor growth and tumor regression (PMID: 21325073).
PD-0325901 PD0325901|PD-901 MEK inhibitor (Pan) 20 MEK1 Inhibitor 20 MEK2 Inhibitor 18 PD-0325901, a derivative of CI-1040, is a pan-MEK inhibitor, which inhibits activation of MAPK/ERK resulting in decreased tumor cell proliferation (PMID: 18952427).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mutant pancreatic ductal adenocarcinoma sensitive PD-0325901 + Gedatolisib Preclinical - Cell culture Actionable In a preclinical study, the addition of combination PD-0325901 to treatment with Gedatolisib (PF-05212384) and PD-0325901 inhibited Gedatolisib (PF-05212384)-enhanced ERK activation, and the combination resulted in decreased proliferation of pancreatic ductal adenocarcinoma cell lines harboring KRAS mutations in culture (PMID: 25673820). 25673820
KRAS act mut ovarian cancer predicted - sensitive PD-0325901 + Gedatolisib Phase I Actionable In a Phase I trial, treatment with the combination of Gedatolisib (PF-05212384) and PD-0325901 resulted in an overall response rate of 11.1% (4/44) and clinical benefit rate of 16.3% (7/44) in patients with a variety of solid tumors, with responses seen in 3 patients with KRAS-mutant ovarian cancer and 1 patient with KRAS-mutant endometrial cancer (PMID: 29067643). 29067643
Clinical Trial Phase Therapies Title Recruitment Status