Therapy Detail

Therapy Name Sirolimus + Celecoxib
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Celecoxib Celebra Celebra (celecoxib) is a COX-2 inhibitor FDA approved as an anti-inflammatory agent and for colorectal polyp reduction (FDA.gov). Celebra (celecoxib) also promotes apoptosis of tumor cells (PMID: 17909047).
Sirolimus Rapamune Rapamycin mTORC1 Inhibitor 8 Rapamune (sirolimus) binds to the FKBP-12 to generate an immunosuppressive complex that binds and allosterically inhibits mTOR (NCI Drug Dictionary, PMID: 25261369). Rapamune (sirolimus) is FDA approved for the prevention of renal transplant rejection and for patients with lymphangioleiomyomatosis (FDA.gov).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown gastric adenocarcinoma not applicable Sirolimus + Celecoxib Preclinical Actionable In a preclinical study, celecoxib enhanced the efficacy of Rapamune (sirolimus) by increasing the growth inhibition of gastric cancer cells in culture (PMID: 25701378). 25701378
Clinical Trial Phase Therapies Title Recruitment Status