Therapy Detail
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| Therapy Name | Temozolomide + Vandetanib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Temozolomide | Temodar | Methazolastone | Chemotherapy - Alkylating 14 | Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary). |
| Vandetanib | Caprelsa | ZD6474 | ABL1 Inhibitor 5 EGFR Inhibitor (Pan) 45 RET Inhibitor 39 SRC Inhibitor 28 VEGFR Inhibitor (Pan) 32 | Caprelsa (vandetanib) is a multi-tyrosine kinase inhibitor with activity against VEGFR, EGFR, RET, SRC, and ABL1 kinases, potentially resulting in decreased tumor growth (PMID: 25031937, PMID: 25490448). Caprelsa (vandetanib) is FDA approved for use in medullary thyroid cancer (FDA.gov). |
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- Case insensitive filtering will display rows where any text in any cell matches the filter term
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- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| Unknown unknown | glioblastoma multiforme | not applicable | Temozolomide + Vandetanib | Phase II | Actionable | In a Phase II trial, Caprelsa (vandetinib), in combination with radiation therapy and Temodar (temozolomide), demonstrated no difference in PFS and OS when compared to radiation therapy and Temodar (temozolomide) alone in glioblastoma patients (PMID: 25910950). | 25910950 |
| IDH1 R132H | glioblastoma multiforme | sensitive | Temozolomide + Vandetanib | Phase II | Actionable | In a Phase II trial, Caprelsa (vandetanib), in combination with Temodar (temozolomide) and radiation therapy, demonstrated a significant increase in PFS and OS in glioblastoma patients harboring IDH1 R132H compared to glioblastoma patients without IDH1 R132H (PMID: 25910950). | 25910950 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|
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