Therapy Detail

Therapy Name INCB039110 + INCB050465
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
INCB050465 PIK3CD inhibitor 24 INCB050465 inhibits PI3K-delta, blocking activation of AKT signaling pathway and leading to apoptosis of PIK3CD expressing tumor cells (NCI Drug Dictionary).
Itacitinib INCB039110 JAK1 Inhibitor 8 Itacitinib (INCB039110) is a selective inhibitor of Janus kinase 1 (JAK1), which may inhibit cell proliferation (PMID: 25605813).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown diffuse large B-cell lymphoma not applicable INCB039110 + INCB050465 Preclinical - Cell line xenograft Actionable In a preclinical study, INCB050465 and INCB039110 combination treatment inhibited proliferation of diffuse large B-cell lymphoma cell lines in culture and induced tumor regression in xenograft models ( Cancer Res August 1, 2015 75; 2671 ). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02018861 Phase I Itacitinib INCB039110 + INCB050465 Bendamustine Rituximab Carboplatin + Etoposide + Ifosfamide INCB050465 A Phase 1, Open-Label, Dose Escalation, Safety and Tolerability Study of INCB050465 Monotherapy and in Combination With INCB039110 in Subjects With Previously Treated B-Cell Malignancies Active, not recruiting
NCT02559492 Phase I INCB039110 + INCB024360 INCB039110 + INCB050465 INCB039110 Combined With INCB024360 and/or INCB039110 Combined With INCB050465 in Advanced Solid Tumors Active, not recruiting