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Therapy Name | Toca 511 |
Synonyms | |
Therapy Description |
Vocimagene Amiretrorepvec (Toca 511) is a retroviral vector encoding yeast cytosine deaminase, which converts the prodrug flucytosine into 5-fluorouracil upon infection of tumor cells, leading to tumor cell death (PMID: 22547150, PMID: 30676111). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Toca 511 | T5.0002|Vocimagene Amiretrorepvec | Chemotherapy - Antimetabolite 14 | Vocimagene Amiretrorepvec (Toca 511) is a retroviral vector encoding yeast cytosine deaminase, which converts the prodrug flucytosine into 5-fluorouracil upon infection of tumor cells, leading to tumor cell death (PMID: 22547150, PMID: 30676111). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT01985256 | Phase I | Toca 511 | Study of a Retroviral Replicating Vector Given Intravenously to Patients Undergoing Surgery for Recurrent Brain Tumor | Completed | USA | 0 |