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|Therapy Name||Imgatuzumab + Irinotecan|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Imgatuzumab||RG7160|GA201|RG-7160|GA-201|RO 5083945|RO5083945||EGFR Antibody 41||Imgatuzumab (RG7160) is a humanized antibody directed against EGFR, which prevents ligand binding and dimerization, resulting in decreased EGFR signaling and increased immune response toward EGFR-expressing tumor cells (PMID: 23209031, PMID: 28950289).|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 10||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|