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Therapy Name | SKF-96365 |
Synonyms | |
Therapy Description |
SKF-96365 is a non-specific inhibitor of store-operated calcium entry, leading to cell-cycle arrest and suppression of tumor cell growth (PMID: 23383239, PMID: 20590636, PMID: 26803057). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
SKF-96365 | SKF 96365|SKF96365 | SKF-96365 is a non-specific inhibitor of store-operated calcium entry, leading to cell-cycle arrest and suppression of tumor cell growth (PMID: 23383239, PMID: 20590636, PMID: 26803057). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Unknown unknown | colorectal cancer | not applicable | SKF-96365 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SKF-96365 treatment inhibited the calcium/calmodulin dependent protein kinase signaling leading to decreased proliferation and increased apoptosis of human colorectal cancer cells in culture and had moderate anti-cancer activity in cell line xenograft models (PMID: 26803057). | 26803057 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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