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|Therapy Name||MEDI5117 + Topotecan|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MEDI5117||MEDI-5117||MEDI5117 is an anti-IL6 monoclonal antibody, which inhibits IL6 autocrine signaling, potentially leading to decreased tumor cell growth (PMID: 26744529, PMID: 27237319).|
|Topotecan||Hycamtin||Topotecan Hcl||Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|