Therapy Detail

Therapy Name MRK-003 + SCH772984
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
MRK-003 Gamma secretase inhibitor 12 MRK-003 is a gamma-secretase inhibitor which inhibits Notch3 signaling and induces apoptosis in cancer cells (PMID: 17804716).
SCH772984 SCH984 ERK Inhibitor (pan) 14 SCH772984 is an ATP-competitive inhibitor of both ERK1 and ERK2, which may result in growth inhibition and tumor regression (PMID: 23614898).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NOTCH1 rearrange triple-receptor negative breast cancer no benefit MRK-003 + SCH772984 Preclinical Actionable In a preclinical study, SCH772984 did not potentiate the growth inhibition effect of MRK-003 in triple receptor-negative breast cancer cells harboring NOTCH1 rearrangement in culture (PMID: 25104330). 25104330
Clinical Trial Phase Therapies Title Recruitment Status