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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SGI-1776||PIM Inhibitor (Pan) 9||SGI-1776 is a small molecule inhibitor of PIMs 1, 2, 3, and FLT-3, which may result in cell death via indirect inhibition of Mcl-1 transcription and protein synthesis (PMID: 21628411, PMID: 32558942).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|JAK2 V617F||bone marrow cancer||decreased response||SGI-1776||Preclinical||Actionable||In a preclinical study, myeloproliferative cancer cell lines harboring JAK2 V617F demonstrated reduced sensitivity to SGI-1776 induced growth inhibition in culture (PMID: 26472029).||26472029|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|