Therapy Detail

Therapy Name Ruxolitinib + SGI-1776
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ruxolitinib Jakafi INCB 18424|INCB018424|INCB18424 JAK1 Inhibitor - ATP competitive 4 JAK2 Inhibitor - ATP competitive 14 Jakafi (ruxolitinib) is an inhibitor of protein tyrosine kinases JAK1 and JAK2, thus resulting in reduced inflammation and reduced proliferation (PMID: 22474318). Jakafi (ruxolitinib) is FDA approved to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis (
SGI-1776 PIM Inhibitor (Pan) 9 SGI-1776 is a small molecule inhibitor of PIMs 1, 2, 3, and FLT-3, which may result in cell death via indirect inhibition of Mcl-1 transcription and protein synthesis (PMID: 21628411).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK2 V617F bone marrow cancer sensitive Ruxolitinib + SGI-1776 Preclinical Actionable In a preclinical study, Jakafi (ruxolitinib) worked synergistically with SGI-1776 to inhibit proliferation of myeloproliferative cancer cell lines harboring JAK2 V617F in culture (PMID: 26472029). 26472029
Clinical Trial Phase Therapies Title Recruitment Status