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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|OPB-31121||OPB 31121||STAT3 Inhibitor 21||OPB-31121 is a small molecule inhibitor of Stat3 that demonstrates antitumor activity (PMID: 23402820, PMID: 25715763, PMID: 25676869, PMID: 24819685).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||OPB-31121||Phase I||Actionable||In a Phase I trial, OPB-31121 treatment resulted in stable diseases in 44% (8/18) of patients with advanced solid tumors, and tumor shrinkage in 2 patients (1 colon cancer, 1 rectal cancer) (PMID: 25715763).||25715763|
|Unknown unknown||hepatocellular carcinoma||no benefit||OPB-31121||Phase I||Actionable||In a Phase I trial, OPB-31121 treatment resulted in only stable disease in 26% (6/23) of patients with advanced hepatocellular carcinoma, and was considered insufficient for clinical efficacy (PMID: 25676869).||25676869|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|