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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GNE-317||mTOR Inhibitor 51 PI3K Inhibitor (Pan) 38||GNE-317 is a dual PI3K/mTOR inhibitor that crosses the blood-brain barrier, resulting in decreased downstream signaling and potentially leading to reduced growth of tumors, including brain tumors (PMID: 22992516, PMID: 28493046).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||melanoma||not applicable||GNE-317||Preclinical - Cell line xenograft||Actionable||In a preclinical study, a melanoma cell line xenograft model demonstrated cell death of metastasized tumor cells within a small region of the brain when treated with GNE-317 (PMID: 27521448).||27521448|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|