Therapy Detail

Therapy Name Phenformin + Sapanisertib
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Phenformin Beta-Pebg Phenformin is a metabolic drug that inhibits mitochondrial complex I, which may lead to decreased tumor growth (PMID: 23352126).
Sapanisertib INK128|sapanisertib|TAK-228|MLN0128 mTOR Inhibitor 48 Sapanisertib (MLN0128) is an ATP-competitive mTOR kinase inhibitor that induces apoptosis and inhibits growth in tumor cells (PMID: 25519700).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KRAS mut STK11 inact mut lung adenocarcinoma sensitive Phenformin + Sapanisertib Preclinical Actionable In a preclinical study, Sapanisertib (MLN0128) in combination with phenformin induced apoptosis and energetic stress in human lung adenocarcinoma cell lines with concurrent KRAS and STK11 (LKB1) mutations in culture, with higher levels than either therapy as a single agent (PMID: 26574479). 26574479
Clinical Trial Phase Therapies Title Recruitment Status