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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ch282-5||BCL2 Family Inhibitor 6||Ch282-5 is a gossypol derivative that binds to and inhibits BCL2, family proteins, resulting in decreased tumor cell growth and increased sensitivity to chemotherapeutic agents (PMID: 26515494, PMID: 29885833).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||Ch282-5||Preclinical||Actionable||In a preclinical study, ch282-5 inhibited growth of a variety of human solid tumor cell lines in culture (PMID: 26515494).||26515494|
|Unknown unknown||colon cancer||not applicable||Ch282-5||Preclinical - Cell line xenograft||Actionable||In a preclinical study, ch282-5 induced apoptosis and inhibited growth and migration of several human and mouse colon cancer cell lines in culture, and inhibited tumor growth and metastasis in xenograft models (PMID: 26515494).||26515494|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|