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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|SKLB646||BRAF Inhibitor 20 CRAF Inhibitor 12 SRC Inhibitor 29 VEGFR2 Inhibitor 35||SKLB646 is a multi-kinase inhibitor with activity against Src, Kdr (Vegfr2), Braf and C-raf (RAF1), resulting in decreased downstream signaling and potentially leading to reduced tumor growth (PMID: 26721945).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||triple-receptor negative breast cancer||not applicable||SKLB646||Preclinical - Cell line xenograft||Actionable||In a preclinical study, SKLB646 inhibited proliferation and migration and induced apoptosis of triple-negative breast cancer (TNBC) cell lines in culture, and inhibited tumor growth in TNBC cell line xenograft models (PMID: 26721945).||26721945|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|