Therapy Name | Radiotherapy + YU238259 |
Therapy Description |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Radiotherapy | ||||
YU238259 | YU238259 is a sulfonamide compound that inhibits homology-dependent DSB repair, therefore sensitizing tumor cells to DSB-inducing treatments (PMID: 26116172). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References | BRCA2 loss | colorectal cancer | sensitive | Radiotherapy + YU238259 | Preclinical | Actionable | In a preclinical study, YU238259 and radiotherapy synergistically inhibited survival of colorectal cancer cell lines harboring BRCA2 loss in culture (PMID: 26116172). | 26116172 |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status |
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