Therapy Detail

Therapy Name AGI-5198 + Radiotherapy
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
AGI-5198 IDH1 Inhibitor 7 AGI-5198 is a selective inhibitor of mutant forms of IDH1, which decreases production of R-2HG, potentially leading to reduced growth of IDH1-mutant tumor cells (PMID: 23558169).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H colorectal cancer resistant AGI-5198 + Radiotherapy Preclinical Actionable In a preclinical study, colorectal cancer cells expressing IDH1 R132H were resistant to radiotherapy when treated with AGI-5198 (PMID: 26363012). 26363012
Clinical Trial Phase Therapies Title Recruitment Status