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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Y078-DM1||RET Inhibitor 39||Y078-DM1 is an antibody drug conjugate composed of a RET antibody (Y078) linked to a derivative of the cytotoxic agent maytansine, which may lead to increased cytotoxicity in RET-expressing tumors (PMID: 26240273).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RET over exp||breast cancer||sensitive||Y078-DM1||Preclinical - Cell line xenograft||Actionable||In a preclinical study, Y078-DM1 induced cytotoxicity in a human breast cancer cell line with high levels of RET expression in culture and inhibited tumor growth in xenograft models (PMID: 26240273).||26240273|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|