Therapy Detail

Therapy Name Docetaxel + MK-5108
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Docetaxel Taxotere Docetaxel anhydrous|Docefrez Antimicrotubule Agent 11 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (NCI Drug Dictionary).
MK-5108 VX-689|MK5018 Aurka Inhibitors 23 MK-5108 is a selective Aurora A kinase inhibitor, which inhibits cell proliferation (PMID: 20053775).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor no benefit Docetaxel + MK-5108 Phase I Actionable In a Phase I clinical trial, the combination of MK-5108 and Taxotere (docetaxel) did not demonstrate improved efficacy over MK-5108 monotherapy in patients with advanced solid tumors, and toxicity of the combination prevented achievement of target therapeutic exposure levels (PMID: 26620496). 26620496
Clinical Trial Phase Therapies Title Recruitment Status