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Therapy Name | Zebularine |
Synonyms | |
Therapy Description |
Zebularine is a cytidine analog that is incorporated into DNA and forms a complex with DNA methyltransferases, resulting in decreased DNA methylation and potentially leading to activation of silenced tumor suppressor genes and decreased tumor cell growth (PMID: 16239434, PMID: 15324698, PMID: 19138966). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Zebularine | 1-beta-D-ribofuranosyl-2(1H)-pyrimidinone | DNMT inhibitor (Pan) 5 | Zebularine is a cytidine analog that is incorporated into DNA and forms a complex with DNA methyltransferases, resulting in decreased DNA methylation and potentially leading to activation of silenced tumor suppressor genes and decreased tumor cell growth (PMID: 16239434, PMID: 15324698, PMID: 19138966). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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