Therapy Detail

Therapy Name Posaconazole
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Posaconazole Noxafil Not Available
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
SMO D473G Advanced Solid Tumor sensitive Posaconazole Preclinical Actionable In a preclinical study, Posaconazole inhibited Hedghog signaling in mouse fibroblasts over expressing murine SMO D477G (corresponding to human SMO D473G) in culture (PMID: 26823493). 26823493
SMO E518K Advanced Solid Tumor sensitive Posaconazole Preclinical Actionable In a preclinical study, Posaconazole inhibited Hedghog signaling in mouse fibroblasts over expressing murine SMO E522K (corresponding to human SMO E518K) in culture (PMID: 26823493). 26823493
SMO N219D Advanced Solid Tumor sensitive Posaconazole Preclinical Actionable In a preclinical study, Posaconazole inhibited Hedghog signaling in mouse fibroblasts over expressing murine SMO N223D (corresponding to human SMO N219D) in culture (PMID: 26823493). 26823493
SMO D384N Advanced Solid Tumor sensitive Posaconazole Preclinical Actionable In a preclinical study, Posaconazole inhibited Hedghog signaling in mouse fibroblasts over expressing murine SMO D388N (corresponding to human SMO D384N) in culture (PMID: 26823493). 26823493
SMO S387N Advanced Solid Tumor sensitive Posaconazole Preclinical Actionable In a preclinical study, Posaconazole inhibited Hedghog signaling in mouse fibroblasts over expressing murine SMO S391N (corresponding to human SMO S387N) in culture (PMID: 26823493). 26823493
SMO W535L Advanced Solid Tumor resistant Posaconazole Preclinical Actionable In a preclinical study, Posaconazole did not inhibit Hedghog signaling in mouse fibroblasts over expressing murine SMO W539L (corresponding to human SMO W535L) in culture (PMID: 26823493). 26823493
Clinical Trial Phase Therapies Title Recruitment Status
NCT03763396 Phase I Posaconazole Ketoconazole Azoles Targeting Recurrent High Grade Gliomas Not yet recruiting