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|Therapy Name||Irinotecan + RG7386|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Irinotecan||Camptosar||CPT-11|Onivyde||TOPO1 inhibitor 10||Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).|
|RG7386||RO6874813|RG 7386|RG-7386||RO6874813 (RG7386) is a bispecific antibody that binds TNFRSF10B (DR5) on tumor cells and fibroblast-activation protein (FAP) found on fibroblasts in the tumor stroma to induce apoptosis (PMID: 27037412).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|