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Therapy Name Domatinostat
Synonyms
Therapy Description

Domatinostat (4SC-202) is a class I histone deacetylase inhibitor that inhibits proliferation and induces apoptosis in tumor cells (PMID: 26773495).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Domatinostat 4SC-202 HDAC Inhibitor 38 Domatinostat (4SC-202) is a class I histone deacetylase inhibitor that inhibits proliferation and induces apoptosis in tumor cells (PMID: 26773495).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown transitional cell carcinoma not applicable Domatinostat Preclinical - Cell culture Actionable In a preclinical study, Domatinostat (4SC-202) inhibited proliferation and induced cell-cycle alterations and cell death in urothelial cancer cell lines in culture (PMID: 27250763). 27250763
Unknown unknown angioimmunoblastic T-cell lymphoma not applicable Domatinostat Case Reports/Case Series Actionable In a Phase I trial, a patient with relapsed angioimmunoblastic T-cell lymphoma demonstrated a complete response lasting over 2 years following treatment with Domatinostat (4SC-202) (PMID: 30347469; NCT01344707). 30347469
Unknown unknown hepatocellular carcinoma not applicable Domatinostat Preclinical - Cell culture Actionable In a preclinical study, Domatinostat (4SC-202) inhibited growth and induced apoptosis in hepatocellular carcinoma cell lines in culture (PMID: 26773495). 26773495
Unknown unknown hematologic cancer not applicable Domatinostat Phase I Actionable In a Phase I trial, treatment with Domatinostat (4SC-202) demonstrated safety and resulted in stable disease in 75% (18/24) and objective response in 2 patients (1 complete response and 1 partial response) with advanced hematological malignancies (PMID: 30347469; NCT01344707). 30347469
Unknown unknown Hodgkin's lymphoma, nodular sclerosis not applicable Domatinostat Case Reports/Case Series Actionable In a Phase I trial, a patient with nodular sclerosis Hodgkin's lymphoma demonstrated a partial response lasting almost 6 months following treatment with Domatinostat (4SC-202) (PMID: 30347469; NCT01344707). 30347469

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  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status


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