Therapy Detail

Therapy Name AZD7762 + Ixazomib
Synonym
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZD7762 CHK Inhibitor (Pan) 2 AZD7762 is an ATP-competitive CHK1/CHK2 inhibitor, which abrogates DNA damage-induced cell cycle checkpoints, and demonstrates antitumor activity when administered in combination with DNA-damaging agents (PMID: 18790776).
Ixazomib Ninlaro MLN9708 Ninlaro (ixazomib) inhibits proteosome activity, resulting in accumulation of misfolded proteins, inhibition of pathway signaling, and potentially leading to cell death (PMID: 20160034).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Hodgkin's lymphoma not applicable AZD7762 + Ixazomib Preclinical Actionable In a preclinical study, Ixazomib (MLN9708) and AZD7762 combination treatment resulted in increased apoptosis in Hodgkin's lymphoma cells in culture (PMID: 26988986). 26988986
Clinical Trial Phase Therapies Title Recruitment Status