Therapy Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Therapy Name PF-06647263
Synonyms
Therapy Description

PF-06647263 is an antibody-drug conjugate consisting of an anti-Ephrin-A4 (EFNA4) monoclonal antibody linked to the drug calicheamicin, which may result in tumor growth inhibition (PMID: 26015513).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
PF-06647263 PF06647263|PF 06647263 PF-06647263 is an antibody-drug conjugate consisting of an anti-Ephrin-A4 (EFNA4) monoclonal antibody linked to the drug calicheamicin, which may result in tumor growth inhibition (PMID: 26015513, PMID: 30680712).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable PF-06647263 Phase I Actionable In a Phase I trial, PF-06647263 treatment demonstrated safety in patients with advanced solid tumors, and resulted in an objective response rate of 10.4% (5/48, 5 partial responses), with an additional 20 patients achieved stable disease (PMID: 30680712; NCT02078752). 30680712
Unknown unknown ovarian cancer not applicable PF-06647263 Case Reports/Case Series Actionable In a Phase I trial, PF-06647263 treatment resulted in 1 partial response and 9 stable disease in patients with ovarian cancer (n=16) (PMID: 30680712; NCT02078752). 30680712
Unknown unknown peritoneum cancer not applicable PF-06647263 Case Reports/Case Series Actionable In a Phase I trial, PF-06647263 treatment resulted in a partial response in a patient with peritoneum cancer (PMID: 30680712; NCT02078752). 30680712

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02078752 Phase I PF-06647263 A Study Of PF-06647263 In Patients With Advanced Solid Tumors Terminated USA 0


Additional content available in CKB BOOST