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Therapy Name | Zibotentan |
Synonyms | |
Therapy Description |
Zibotentan (ZD4054) is an antagonist of the ET(A) endothelin receptor, which results in decreased ET-1/ET(A)-mediated signaling, and may lead to decreased proliferation and increased apoptosis of tumor cells and reduced tumor growth (PMID: 17620430, PMID: 18616419, PMID: 30937921). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Zibotentan | ZD4054 | Zibotentan (ZD4054) is an antagonist of the ET(A) endothelin receptor, which results in decreased ET-1/ET(A)-mediated signaling, and may lead to decreased proliferation and increased apoptosis of tumor cells and reduced tumor growth (PMID: 17620430, PMID: 18616419, PMID: 30937921). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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