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|Therapy Name||JQ1 + MRK-003|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|JQ1||BET Inhibitor (Pan) 27||JQ1 is a BET bromodomain inhibitor with greatest specificity towards BRD4, resulting in decreased Myc expression, increased cell death, reduced macrophage immunosuppression, and inhibition of tumor growth (PMID: 24231268, PMID: 31018997, PMID: 30906568).|
|MRK-003||Gamma secretase inhibitor 12||MRK-003 is a gamma-secretase inhibitor which inhibits Notch3 signaling and induces apoptosis in cancer cells (PMID: 17804716).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||brain stem glioma||not applicable||JQ1 + MRK-003||Preclinical - Cell culture||Actionable||In a preclinical study, the combination of MRK-003 and JQ1 resulted in increased apoptosis of diffuse pontine glioma cell lines in culture, compared to either agent alone (PMID: 26115193).||26115193|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|