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|Therapy Name||NSC-87877 + PLX4720|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NSC-87877||NSC87877|NSC 87877||NSC-87877 is an inhibitor of Shp2, which may result in inhibition of Erk1/2 activation and decreased cell proliferation (PMID: 16717135, PMID: 30388134).|
|PLX4720||PLX-4720|PLX 4720||BRAF Inhibitor 21||PLX4720 is a 7-azaindole derivative and RAF kinase inhibitor with greater affinity for BRAF V600E than BRAF wild-type, which may induce cell cycle arrest and apoptosis, and lead to tumor growth inhibition and regression (PMID: 18287029).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|