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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NSC126405||NSC126405 is a small molecule inhibitor of DEPTOR, which prevents binding to Mtor, possibly resulting in apoptotic activity and cell cycle arrest (PMID: 27530328, PMID: 31395691).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||multiple myeloma||not applicable||NSC126405||Preclinical - Cell line xenograft||Actionable||In a preclinical study, NSC126405 inhibited tumor growth during 11 days of treatment in multiple myeloma cell line xenograft models and 22% (2/9) of the mice demonstrated tumor regression post treatment (PMID: 27530328).||27530328|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|