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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|NGI-1||ML414||NGI-1 inhibits the activity of oligosacchyltransferase, which results in reduced N-linked glycosylation and may lead to decreased proliferation of tumor cells with dependence on receptor tyrosine kinase signaling (PMID: 27694802, PMID: 31511384).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR1 amp||lung non-small cell carcinoma||predicted - sensitive||NGI-1||Preclinical - Cell culture||Actionable||In a preclinical study, NGI-1 inhibited FGFR1 phosphorylation and proliferation of a FGFR1-amplified cell line dependent on FGFR1 signaling in culture, however, did not inhibit proliferation of an FGFR1-amplified cell line not dependent on FGFR1 signaling (PMID: 27694802).||27694802|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|