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|Therapy Name||Everolimus + Radiotherapy|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Everolimus||Afinitor||RAD001|Zortress||mTORC1 Inhibitor 9||Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|STK11 F298L||pituitary carcinoma||predicted - sensitive||Everolimus + Radiotherapy||Case Reports/Case Series||Actionable||In a clinical case study, a patient with adenocorticotropic pituitary carcinoma harboring STK11 F298L demonstrated stable disease and clinical benefit for greater than 6 months following treatment with Afinitor (everolimus), along with radiotherapy (PMID: 27615706).||27615706|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|