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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|GDC-0326||PIK3CA inhibitor 16||GDC-0326 is a small molecule that inhibits PIK3CA, resulting in decreased downstream signaling and potentially leading to reduced tumor growth (PMID: 27225693).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||islet cell tumor||not applicable||GDC-0326||Preclinical||Actionable||In a preclinical study, GDC-0326 inhibited AKT activation, decreased tumor growth, metastasis, and angiogenesis and increased lifespan in a transgenic mouse model of pancreatic neuroendocrine tumor (PMID: 27225693).||27225693|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|