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Therapy Name | AMI-408 |
Synonyms | |
Therapy Description |
AMI-408 inhibits PRMT1, potentially resulting in decreased tumor cell growth (PMID: 26766589). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
AMI-408 | AMI-408 inhibits PRMT1, potentially resulting in decreased tumor cell growth (PMID: 26766589). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A - GAS7 | leukemia | sensitive | AMI-408 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with AMI-408 decreased growth of leukemia cells expressing KMT2A-GAS7 (MLL-GAS7) in culture, and increased survival in xenograft models (PMID: 26766589). | 26766589 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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