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Therapy Name INCB059872
Synonyms
Therapy Description

INCB059872 is a specific inhibitor of lysine specific demethylase 1 (KDM1A, LSD1) that increases tumor-suppressor gene expression through enhancing Histone H3 methylation, leading to anti-tumor effects (Cancer Res 2016;76(14 Suppl):Abstract nr 4704).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
INCB059872 KDM1A Inhibitor 12 INCB059872 is a specific inhibitor of lysine specific demethylase 1 (KDM1A, LSD1) that increases tumor-suppressor gene expression through enhancing Histone H3 methylation, leading to anti-tumor effects (Cancer Res 2016;76(14 Suppl):Abstract nr 4704, PMID: 32422235).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown lung non-small cell carcinoma not applicable INCB059872 Preclinical - Cell line xenograft Actionable In a preclinical study, INCB059872 inhibited growth of non-small cell lung carcinoma cell lines in culture and in cell line xenoraft models (Cancer Res 2016;76(14 Suppl):Abstract nr 4704). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT03514407 Phase I INCB059872 A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma Terminated
NCT02712905 Phase Ib/II INCB059872 An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies Terminated


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