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Drug Name Trade Name Synonyms Drug Classes Drug Description
Dactolisib NVP-BEZ235|BEZ235 ATR Inhibitor 10 mTOR Inhibitor 51 PI3K Inhibitor (Pan) 37 Dactolisib (BEZ235) inhibits PI3K kinase, mTOR kinase, and ATR, which may result in tumor cell apoptosis and growth inhibition of tumor cells (PMID: 18606717, PMID: 21552262, PMID: 32088816).
unspecified CTLA4 antibody experimental CTLA4 antibody
unspecified PD-1 antibody Experimental PD-1 antibody PD-L1/PD-1 antibody 63

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown prostate cancer not applicable Dactolisib + unspecified CTLA4 antibody + unspecified PD-1 antibody Preclinical Actionable In a preclinical study, combination of myeloid-derived suppressor cell-targeting with BEZ235 and immune checkpoint blockade with anti-CTLA4 and anti-PD-1 antibodies resulted in synergistic inhibition of tumor growth and metastasis in transgenic mouse models of metastatic castration-resistant prostate cancer (PMID: 28321130). 28321130

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Clinical Trial Phase Therapies Title Recruitment Status


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