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|Therapy Name||Cisplatin + KPT-185|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Cisplatin||Platinol||CDDP||Chemotherapy - Platinum 7||Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).|
|KPT-185||KPT185||KPT-185 is a small molecule inhibitor of the nuclear export, XPO1 (CRM1), preventing export of tumor suppressor proteins thereby possibly restoring tumor suppressor function in the cell and thus, leading to apoptotic activity (PMID: 25579209). KPT-185 has been demonstrated to be unsuitable for in vivo studies due to weak pharmacokinetic properties (PMID: 23373539).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|