Therapy Detail

Therapy Name 3144
Synonym
Therapy Description

3144 is a Pan-RAS inhibitor, which binds to KRAS, NRAS, and HRAS proteins and decreases RAS-mediated signaling, and may reduce growth of RAS-dependent tumors (PMID: 28235199).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
3144 RAS Inhibitor (Pan) 7 3144 is a Pan-RAS inhibitor, which binds to KRAS, NRAS, and HRAS proteins and decreases RAS-mediated signaling, and may reduce growth of RAS-dependent tumors (PMID: 28235199).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G13V adult T-cell leukemia sensitive 3144 Preclinical - Pdx & cell culture Actionable In a preclinical study, 3144 inhibited growth of patient-derived T-cell acute lymphocytic leukemia cells harboring NRAS G13V in culture, and reduced tumor burden in xenograft models (PMID: 28235199). 28235199
KRAS G13D breast cancer sensitive 3144 Preclinical - Cell line xenograft Actionable In a preclinical study, 3144 inhibited growth of a breast cancer cell line harboring KRAS G13D in culture and reduced tumor growth in xenograft models (PMID: 28235199). 28235199
NRAS G13D adult T-cell leukemia sensitive 3144 Preclinical - Cell culture Actionable In a preclinical study, 3144 inhibited growth of patient-derived T-cell acute lymphocytic leukemia cells harboring NRAS G13D in culture (PMID: 28235199). 28235199
KRAS G12V colorectal cancer sensitive 3144 Preclinical - Cell culture Actionable In a preclinical study, 3144 inhibited growth of a colorectal cancer cell line harboring KRAS G12V in culture (PMID: 28235199). 28235199
Clinical Trial Phase Therapies Title Recruitment Status