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E7046 is a small molecule inhibitor of E2 receptor type 4 (EP4), which may result in antitumor activity including inhibition of cell proliferation and reduced tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198).
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|E7046||AN0025|E-7046|E 7046||AN0025 (E7046) is a small molecule inhibitor of E2 receptor type 4 (EP4), which may result in antitumor activity including inhibition of cell proliferation and reduced tumor growth (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198, PMID: 32554609).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||not applicable||E7046||Preclinical||Actionable||In a preclinical study, multiple mouse tumor models demonstrated inhibition of tumor growth when treated with E7046 (Cancer Immunol Res 2016;4(1 Suppl):Abstract nr B034).||detail...|
|Unknown unknown||Advanced Solid Tumor||not applicable||E7046||Phase I||Actionable||In a Phase I trial, AN0025 (E7046) treatment was tolerated, demonstrated on target activity as indicated by upregulation of EP4 downstream genes and enhanced anti-tumor immune response, and resulted in stable disease as best response in 23% (7/30) of patients with advanced solid tumors, and 3 patients achieved metabolic responses (PMID: 32554609; NCT02540291).||32554609|
|Unknown unknown||colon cancer||not applicable||E7046||Preclinical||Actionable||In a preclinical study, a colon cancer mouse model harboring an APC mutation demonstrated decreased polyp formation and decreased cell proliferation when treated with the EP4 antagonist, E7046 (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr B198).||detail...|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02540291||Phase I||E7046||Study of E7046 in Subjects With Selected Advanced Malignancies||Terminated||USA||1|