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Therapy Name Teclistamab
Synonyms
Therapy Description

Tecvayli (teclistamab) is a bispecific antibody that targets CD3 and BCMA, potentially resulting in increased immune response against BCMA-expressing tumor cells (Blood Dec 2016, 128 (22) 5668). Tecvayli (teclistamab) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Teclistamab Tecvayli JNJ-64007957|BCMAxCD3|JNJ 64007957|JNJ64007957 CD3 Antibody 96 TNFRSF17 Antibody 19 Tecvayli (teclistamab) is a bispecific antibody that targets CD3 and BCMA, potentially resulting in increased immune response against BCMA-expressing tumor cells (Blood Dec 2016, 128 (22) 5668). Tecvayli (teclistamab) is FDA approved for use in adult patients with relapsed or refractory multiple myeloma who have received four or more prior lines of therapy (FDA.gov).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05463939 Expanded access Teclistamab Teclistamab Expanded Access Treatment Protocol for Relapsed or Refractory Multiple Myeloma Patients Approved for marketing 0
NCT06425991 Phase I Teclistamab A Study Comparing Pre- and Post-Change Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-10) Recruiting USA | ITA | GBR | FRA | ESP | AUS 2
NCT05572515 Phase III Teclistamab Carfilzomib + Dexamethasone Bortezomib + Dexamethasone + Pomalidomide A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (MajesTEC-9) Recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL | AUT | AUS 13
NCT05469893 Phase II Teclistamab Dexamethasone + Lenalidomide Immuno-PRISM (PRecision Intervention Smoldering Myeloma) Recruiting USA 0
NCT03145181 Phase I Teclistamab Dose Escalation Study of JNJ-64007957, a Humanized BCMA CD3 DuoBody® Antibody, in Participants With Relapsed or Refractory Multiple Myeloma Recruiting USA | NLD | FRA | ESP 1
NCT04557098 Phase II Teclistamab A Study of Teclistamab, in Participants With Relapsed or Refractory Multiple Myeloma Active, not recruiting USA | NLD | ITA | GBR | FRA | ESP | DEU | CAN | BEL 2


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