Therapy Detail

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Therapy Name Zenocutuzumab
Synonyms
Therapy Description

MCLA-128 is a bispecific antibody that targets Erbb2 (Her2) and Erbb3, resulting in antibody-dependent cell-mediated cytotoxicity against tumor cells (Cancer Res 2016;76(14 Suppl):Abstract nr CT050).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Zenocutuzumab MCLA-128|MCLA128|MCLA 128 Zenocutuzumab (MCLA-128) is a bispecific antibody that targets Erbb2 (Her2) and Erbb3, resulting in antibody-dependent cell-mediated cytotoxicity against tumor cells (Cancer Res 2016;76(14 Suppl):Abstract nr CT050, PMID: 32054397).

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Zenocutuzumab Phase Ib/II Actionable In a Phase I/II trial, Zenocutuzumab (MCLA-128) demonstrated safety and preliminary efficacy, resulted in partial response in 3.6% (1/28) and stable disease in 7.1% (2/28) of patients with advanced solid tumors (Cancer Res 2016;76(14 Suppl):Abstract nr CT050). detail...
Unknown unknown gastroesophageal junction adenocarcinoma not applicable Zenocutuzumab Phase Ib/II Actionable In a Phase I/II trial, Zenocutuzumab (MCLA-128) resulted in stable disease for 5 months in a patient with gastroesophageal junction cancer (Cancer Res 2016;76(14 Suppl):Abstract nr CT050). detail...
Unknown unknown lung non-small cell carcinoma not applicable Zenocutuzumab Phase Ib/II Actionable In a Phase I/II trial, Zenocutuzumab (MCLA-218) resulted in partial response for more than 10 months in a patient with non-small cell lung cancer (Cancer Res 2016;76(14 Suppl):Abstract nr CT050). detail...
Unknown unknown colorectal cancer not applicable Zenocutuzumab Phase Ib/II Actionable In a Phase I/II trial, Zenocutuzumab (MCLA-128) resulted in stable disease for 5 months in a patient with colorectal cancer (Cancer Res 2016;76(14 Suppl):Abstract nr CT050). detail...

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Clinical Trial Phase Therapies Title Recruitment Status
NCT02912949 Phase Ib/II Zenocutuzumab A Study of Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion Recruiting


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