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|Therapy Name||MVT-1075 + MVT-5873|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MVT-1075||MVT-1075 is a radiolabeled IgG1 antibody that binds to the sialyl Lewis A epitope of CA19-9 and is conjugated to a bifunctional chelator, which may result in tumor growth inhibition and tumor regression (AACR 2017, Abstract nr5204).|
|MVT-5873||HuMab 5B1|HuMab-5B1||MVT-5873 (HuMab-5B1) is an IgG1 antibody that binds to the sialyl Lewis A epitope of CA19-9, which may result in antitumor activity including tumor growth inhibition (Cancer Res 2016;76(24 Suppl):Abstract nr A73, PMID: 32399263).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT03118349||Phase I||MVT-1075 + MVT-5873||Study of 177Lu Human Monoclonal Antibody 5B1 (MVT-1075) in Combination With a Blocking Dose of MVT-5873 as Radioimmunotherapy||Active, not recruiting|