Therapy Detail

Therapy Name V158411
Therapy Description

V158411 is a small molecule that selectively inhibits CHK1, which results in increased DNA damage, and potentially leads to decreased growth of tumor cells (PMID: 27829224, PMID: 24913641).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
V158411 CHK1 Inhibitor 14 V158411 is a small molecule that selectively inhibits CHK1, which results in increased DNA damage, and potentially leads to decreased growth of tumor cells (PMID: 27829224, PMID: 24913641).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown breast cancer not applicable V158411 Preclinical - Cell culture Actionable In a preclinical study, V158411 induced DNA damage and cell-cycle arrest, and inhibited growth of a breast cancer cell line in culture (PMID: 27829224). 27829224
Unknown unknown osteosarcoma not applicable V158411 Preclinical - Cell culture Actionable In a preclinical study, V158411 inhibited Chk1 autophosphorylation and induced DNA damage and apoptosis in an osteosarcoma cell line in culture (PMID: 27829224). 27829224
Unknown unknown melanoma not applicable V158411 Preclinical - Cell culture Actionable In a preclinical study, V158411 induced DNA damage and cell-cycle arrest, and inhibited growth of a melanoma cell line in culture (PMID: 27829224). 27829224
Unknown unknown colorectal cancer not applicable V158411 Preclinical - Cell culture Actionable In a preclinical study, V158411 inhibited Chek1 autophosphorylation, induced DNA damage and cell-cycle arrest, and inhibited growth of a colorectal cancer cell line in culture (PMID: 27829224). 27829224
Clinical Trial Phase Therapies Title Recruitment Status