Therapy Detail

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Therapy Name AU-011
Synonyms
Therapy Description

AU-011 is a photodynamic therapy comprised of human papilloma virus derived nanoparticles conjugated to infrared dye, IR700, which upon irradiation results in reactive oxygen species generation and thus, subsequent cell death (Cancer Res 2014;74(19 Suppl):Abstract nr 1770).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AU-011 AU-011 is a photodynamic therapy comprised of human papilloma virus derived nanoparticles conjugated to infrared dye, IR700, which upon irradiation results in reactive oxygen species generation and thus, subsequent cell death (Cancer Res 2014;74(19 Suppl):Abstract nr 1770, PMID: 30844944).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown uveal melanoma not applicable AU-011 Preclinical - Cell culture Actionable In a preclinical study, treatment with AU-011 resulted in cell binding and subsequent cell death in uveal melanoma cells in culture (Cancer Res 2014;74(19 Suppl):Abstract nr 1770). detail...

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03052127 Phase I AU-011 Phase 1B Study in Subjects With Small to Medium Primary Choroidal Melanoma Completed USA 0
NCT04417530 Phase II AU-011 Phase 2 Trial of AU-011 Via Suprachoroidal Administration With a Dose Escalation and Randomized, Masked Dose Expansion Designed to Evaluate Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma Recruiting USA 0


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