Therapy Detail

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Therapy Name AU-011
Synonyms
Therapy Description

AU-011 is a photodynamic therapy comprised of human papilloma virus derived nanoparticles conjugated to infrared dye, IR700, which upon irradiation results in reactive oxygen species generation and thus, subsequent cell death (Cancer Res 2014;74(19 Suppl):Abstract nr 1770, PMID: 30844944).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AU-011 AU-011 is a photodynamic therapy comprised of human papilloma virus derived nanoparticles conjugated to infrared dye, IR700, which upon irradiation results in reactive oxygen species generation and thus, subsequent cell death (Cancer Res 2014;74(19 Suppl):Abstract nr 1770, PMID: 30844944).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06007690 Phase III AU-011 A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma (CoMpass) Recruiting USA 0
NCT03052127 Phase I AU-011 Phase 1B Study in Subjects With Small to Medium Primary Choroidal Melanoma Completed USA 0
NCT05483868 Phase I AU-011 A Phase 1, Open-label Trial of AU-011 (Belzupacap Sarotalocan) in NMIBC Recruiting USA 0
NCT04417530 Phase II AU-011 Phase 2 Trial of AU-011 Via Suprachoroidal Administration With a Dose Escalation and Randomized, Masked Dose Expansion Designed to Evaluate Safety and Efficacy of AU-011 in Subjects With Primary Indeterminate Lesions and Small Choroidal Melanoma Active, not recruiting USA 0


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